Threshers has opened up its franchise scheme to the public after store managers and employees were given first refusal.
Six hundred stores were set aside for the scheme in January and since then more than 300 managers have shown an interest in taking on an off licence.
Under the Thresher Franchise initiative, applicants are expected to pay about £20,000, plus stock value, to take over the store and run it as their own business. Franchisees will be able to make many local decisions about the range, pricing and promotions, to maximise sales and profit.
Chief executive officer Roger Whiteside said: "Having selected only the stores that have demonstrated sustained profitability, the scheme offers a unique opportunity for anyone interested in owning a branded off licence franchise, backed by the biggest name in the business."